Kentucky Wildcats vs Iowa State Cyclones Prediction: NCAA Tournament Second Round


The Round of 32 in the 2026 NCAA Tournament includes a clash between Kentucky and Iowa State on Sunday. One side is a battle-tested Kentucky group that survived an overtime scare in the opening round, while Iowa State enters off one of the most dominant first-round wins of the tournament. With a trip to the Sweet 16 on the line, this Kentucky vs Iowa State game is expected to be close on Sunday in St. Louis.
https://www.youtube.com/watch?v=a3a3j__ovRc

Kentucky advanced after an 89-84 overtime win in the first round, leaning heavily on a standout performance from Otega Oweh. That game highlighted both the Wildcats’ scoring ceiling and their defensive concerns, as they allowed a double-digit seed to push them to the brink.
Iowa State, on the other hand, cruised to a 108-74 win in its opener, showcasing offensive balance and depth. However, the biggest storyline heading into this contest is the status of forward Joshua Jefferson, who is dealing with an ankle injury and is considered unlikely to play. His absence would remove a key piece from Iowa State’s lineup on both ends of the floor.
Iowa State Cyclones
Kentucky Wildcats
Stat | Kentucky | Iowa State |
|---|---|---|
Points per game | 81.0 | 82.5 |
Points allowed per game | 74.1 | 65.4 |
Team Field Goal % | 47% | 49% |
Rebounds per game | 37.6 | 35.8 |
Assists per game | 16.1 | 17.4 |
Iowa State enters this matchup as the more complete team, particularly on the defensive end, where it allows just over 65 points per game. The Cyclones also hold an edge in ball movement and efficiency, factors that typically translate well in tournament settings.
That said, the potential absence of Joshua Jefferson cannot be ignored. His production across scoring, rebounding, and playmaking leaves a noticeable gap. Kentucky’s path to an upset lies in another high-level performance from Oweh and improved execution in late-game situations.
In the end, Iowa State’s depth and defensive tenacity should be enough to advance, though the margin may be tighter than expected. Laying the points with the Cyclones is my preferred angle, but but with only a moderate level of confidence.
Affiliate DisclosureATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.