New Orleans Pelicans vs Memphis Grizzlies Prediction - 10/22/2025
Updated July 9, 2026
The New Orleans Pelicans and Memphis Grizzlies will open the 2025-26 NBA regular season against each other on Wednesday night. Memphis comes into this season hoping that their stars can stay healthy so that they can live up to expectations. New Orleans knows plenty about that, as their hopes this season are pinned to the health of Zion Williamson. Before these teams tip off their season on Wednesday, keep reading to get my Pelicans vs Grizzlies prediction.
Market | Line |
|---|---|
Spread | Grizzlies –4.5 |
Moneyline | Grizzlies –200, Pelicans +170 |
Total | 237.5 points |
The Grizzlies swept the Pelicans in their four regular-season games last year. Two of those wins for the Grizzlies came by double-digits and those were the two games they played in Memphis. The Grizzlies will aim for a similar result and margin of victory at home in this game.
Player | Prop to Watch |
|---|---|
Ja Morant | Over 23.5 points |
Jaren Jackson Jr. | Over 1.5 3-pointers made |
Zion Williamson | Over 20.5 points |
Score Projection: New Orleans Pelicans 108 – Memphis Grizzlies 114
Win Probability: Memphis 65%, New Orleans 35%
We are going to learn a lot about both of these teams in this matchup to start the season. We should see the Grizzlies assert their dominance early on, as the Pelicans are at a significant disadvantage from a continuity standpoint. I'll take the Grizzlies to win and cover the spread at home here, even without Edey to give them a size advantage.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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