Clemson vs North Carolina Pick & Prediction - 10/4/2025
Updated June 8, 2026
Clemson and North Carolina will meet on Saturday afternoon in a college football game between two desperate programs. These might be the two most disappointing teams in college football so far this season, but one of them has to win this matchup from Chapel Hill. Here, I analyze this conference game in the ACC and give you my Clemson vs North Carolina prediction for Saturday afternoon's game.
Spread | Moneyline | Total |
|---|---|---|
Clemson –14 | Clemson –700 / UNC +450 | 46.5 |
Clemson signal-caller Cade Klubnik has been under scrutiny this year. Turnovers have plagued him, and the offense has lacked explosiveness. If he can settle down and avoid mistakes, Clemson should win this game against a struggling opponent.
North Carolina quarterback Gio Lopez is listed as questionable to play in this contest. He has three touchdowns and three interceptions so far this season. If he plays, he needs to play better to help the Tar Heels win this contest. But he also might be the best option that North Carolina has at this time.
Score Projection: Clemson 34 – North Carolina 17
Win Probability: Clemson 78%, North Carolina 22%
I don't feel good about trusting either of these teams to deliver anything for me in betting markets right now. But if I had to choose, I would go with the Clemson Tigers to cover the spread on the road here. The Tigers should take advantage of North Carolina's quarterback situation and this line could move further in Clemson's direction if Lopez is unable to suit up for the Tar Heels' ACC opener.
