Northwestern vs Nebraska Pick & Prediction - 10/25/2025
Updated July 9, 2026
The Northwestern Wildcats and Nebraska Cornhuskers will face off in Big Ten play on Saturday afternoon. Both squads arrive with identical 5-2 records and the winner will get to six wins and lock up bowl eligibility with plenty of games to spare. Nebraska is favored at home in Lincoln and they will try to end the winning streak of Northwestern. Before this game begins, continue reading to get my Northwestern vs Nebraska prediction.
Nebraska starter Dylan Raiola has thrown for 1,768 yards with 16 touchdowns and five interceptions. His protection has been inconsistent and the recent Minnesota game exposed issues in the pocket and with his red-zone execution.
Northwestern passes for only 174.3 yards per game (ranked 115th nationally) while rushing for 190.1 yards per game (ranked 39th). Quarterback Preston Stone has 10 touchdown passes and seven interceptions for the year.
Score Projection: Nebraska 27 – Northwestern 24
Win Probability: Nebraska 68%, Northwestern 32%
This game will come down to whether Nebraska can protect the quarterback and finish drives against a disciplined Northwestern defense. I think that Nebraska will ultimately win this game at home. But I don't think that it is going to be easy by any stretch of the imagination. I recommend taking the points with Northwestern, as they will make this an ugly game that will come down to a possession in Lincoln.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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