Virginia vs Louisville Pick & Prediction - 10/4/2025
Updated July 9, 2026
The Virginia Cavaliers will visit the Louisville Cardinals in college football on Saturday. The Cavaliers are ranked 24th in the country going into this week at 4-1. But they are underdogs against an unranked Louisville team that is 4-0 on the year entering this contest. Here, I take a closer look at this important ACC matchup and you can continue reading to get my Virginia vs Louisville prediction.
Virginia – Chandler Morris: Morris has been exceptional this season, showcasing his ability to make plays both in the air and on the ground. His performance against Florida State highlighted his poise and playmaking ability under pressure. He has 1,279 passing yards, 10 touchdowns, and four interceptions on the season.
Louisville – Miller Moss: Louisville's Miller Moss has thrown for 1,029 yards, five touchdowns, and three interceptions. His touchdown numbers haven't been spectacular, but he's been effective enough to help his team to an unbeaten start.
Score Projection: Louisville 37 – Virginia 27
Win Probability: Louisville 72.6%, Virginia 27.4%
I am expecting Louisville to remain undefeated by getting a win at home over Virginia on Saturday. The Cardinals proved last week that they can slow down potent passing attacks from their opposition. And with the Cards being at home here, they should be able to rely on their crowd to help further disrupt Chandler Morris and the Cavaliers. Virginia should drop to 0-2 on the road for the season with a loss by over a touchdown here.
