BYU vs Iowa State Pick & Prediction - 10/25/2025
Updated July 9, 2026
The BYU Cougars and Iowa State Cyclones will meet in a huge Big 12 matchup on Saturday afternoon. The Cougars come into this game undefeated on the season and will try to stay that way after a tough road test against the Cyclones. Here, I break down this big game in the Big 12 and make my BYU vs Iowa State prediction from Ames.
Score Projection: BYU 25 – Iowa State 31
Win Probability: BYU 43%, Iowa State 57%
This game features a compelling matchup between BYU's high-powered offense and Iowa State's defense. While the Cyclones have struggled in recent outings, their home-field advantage and strong defensive front could pose challenges for the Cougars. I think that this game is the perfect opportunity to bet against BYU. Expect the Cougars' undefeated start to the season to come to an end and for the Cyclones to cover the spread as favorites on their home turf.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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