Missouri vs Vanderbilt Pick & Prediction - 10/25/2025
Updated July 9, 2026
The Missouri Tigers and Vanderbilt Commodores will meet in the SEC on Saturday afternoon in Nashville. This game is a battle of two surprising SEC teams, with both sides entering this game with just one loss on the season. Before kickoff in this huge contest in college football, continue reading to get my Missouri vs Vanderbilt prediction.
Diego Pavia has been instrumental in Vanderbilt's offensive success, combining for over 2,000 total yards and 19 touchdowns this season. His dual-threat capability adds a dynamic element to the Commodores' offense. Beau Pribula has been consistent for Missouri, with over 1,600 passing yards and 11 touchdowns. However, his performance in high-pressure situations will be crucial in this matchup.
Score Projection: Vanderbilt 30 – Missouri 24
Win Probability: Vanderbilt 58%, Missouri 42%
This SEC showdown features two high-powered offenses and should be a lot of fun to watch. Vanderbilt's home-field advantage and recent momentum give them a slight edge. While Missouri's defense has been formidable, Vanderbilt's offensive balance and playmaking ability with Pavia are expected to prevail in this closely contested game in the SEC.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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