Cal vs Louisville Pick & Prediction - 11/8/2025
Updated July 9, 2026
Louisville will host California in an important game in the ACC on Saturday night. The Cardinals have lost just one conference game so far this season and will look to keep their hopes of reaching the ACC title game alive with a win here. Cal will attempt to pull off an upset on the road behind the play of their talented freshman quarterback. Who will get the job done in Kentucky? You can find my Cal vs Louisville prediction below before the action begins.
Louisville quarterback Miller Moss has completed right around two-thirds of his passes this season. He has logged 1,929 passing yards with 11 touchdowns and 6 interceptions. Limiting mistakes and forcing Cal to go the length of the field to score will be key for Moss and his team in this game.
Cal's Jaron‑Keawe Sagapolutele is a true freshman making his first extended run as the starting QB at the collegiate level. He has thrown for 2,195 yards, 11 touchdowns, and 9 interceptions. The defense he faces in Louisville will test his adjustment to ACC‑level competition.
Score Projection: California 17 – Louisville 35
Win Probability: Louisville 78%, California 22%
We should see enough scoring on both sides to get this game over the total. Louisville will do the majority of the scoring in this contest. But Cal will do its part thanks to the passing of JKS while the Golden Bears are playing catch-up in the second half. My best bet for this important ACC game is the over.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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