Northwestern vs Penn State Pick & Prediction - 10/11/2025
Updated July 9, 2026
The Penn State Nittany Lions will host the Northwestern Wildcats on Saturday afternoon. Penn State has lost two games in a row and went from being an elite team to being unranked in the blink of an eye. They will try to get back on track at home against a middling Northwestern team. Here, you will find my Northwestern vs Penn State prediction before this Big Ten game kicks off.
Odds | Spread | Moneyline | Total |
|---|---|---|---|
Penn State | -21.5 | -1800 | Over 48.5 |
Northwestern | +21.5 | +900 | Under 48.5 |
Preston Stone leads Northwestern with 918 passing yards and seven touchdowns. However, his six interceptions indicate that he can make questionable decisions under duress. Penn State's Drew Allar has been efficient with 963 passing yards and eight touchdowns, maintaining a 64.7% completion rate. Allar will try to bounce back from a disappointing last couple of games and get his team its first Big Ten win of the season.
This game is a great opportunity for Penn State to bounce back from a disappointing start to their Big Ten campaign. The Nittany Lions should take advantage of Stone's sloppy play at quarterback for Northwestern. I'll lay the points with Penn State here, as they should get their first conference win of the season in style.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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