Ohio State vs Wisconsin Pick & Prediction - 10/18/2025
Updated July 9, 2026
The Ohio State Buckeyes are ranked number one in the country and they will try to stay there as they face the Wisconsin Badgers this week. Ohio State is a huge favorite going into this game and Wisconsin will try to knock them off their perch at Camp Randall Stadium here. Before Saturday's marquee matchup in the Big Ten, continue reading to get my Ohio State vs Wisconsin prediction.
Odds | Spread | Total |
|---|---|---|
Ohio State | -25.5 | Over 41.5 |
Wisconsin | +25.5 | Under 41.5 |
Ohio State's sophomore quarterback Julian Sayin has been exceptional this season. Sayin is leading the Big Ten in completion percentage and quarterback rating. He has 1,479 passing yards and 15 touchdowns against just three interceptions. Sayin has been a key factor in the Buckeyes' offensive success.
Wisconsin has struggled at the quarterback position due to injuries and inconsistency. Billy Edwards Jr. remains sidelined with a knee injury, and neither Danny O'Neil nor Hunter Simmons has been able to provide stability. Simmons was held to just 82 passing yards and completed eight of his 21 pass attempts in last week's 37-0 loss to Iowa.
Ohio State might have the best defense in the country going into this game. The Buckeyes have allowed 6.8 points per game this season. That number is the best in college football by a full field goal per game over second-place Oklahoma. The Buckeyes will have to like their chances on that side of the ball against a struggling Wisconsin defense.
Wisconsin's defense has not fared well against power conference opponents. They have given up 31.5 points per game in their last four games. Those games came against Alabama and a trio of Big Ten opponents. The Badgers have to be better on that side of the ball if they want any shot at slowing down Sayin and the Buckeyes.
Score Projection: Ohio State 31 – Wisconsin 7
Win Probability: Ohio State 91.5%, Wisconsin 8.5%
Ohio State should dominate this game with their defense as they have done in all of their other games so far this season. The hot seat will only get hotter for Wisconsin head coach Luke Fickell after this game. I think the Buckeyes win convincingly, but my best bet for this contest will be the under, as there is a real shot that Ohio State pitches a shutout on the road in this one.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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