SMU vs Wake Forest Pick & Prediction - 10/25/2025
Updated July 9, 2026
The SMU Mustangs (5-2, 3-0 ACC) will travel to Winston-Salem to face the Wake Forest Demon Deacons (4-2, 1-2 ACC) on Saturday afternoon. This Atlantic Coast Conference matchup features two teams with winning records, but SMU enters the game with a perfect conference record and will try to stay unbeaten in ACC play. Before this matchup kicks off, continue reading to get my SMU vs Wake Forest prediction.
SMU's Kevin Jennings has been a standout this season for the Mustangs. He has thrown for 1,948 yards with 17 touchdowns and seven interceptions. His performance has been instrumental in the Mustangs' offensive success. Wake Forest's Robby Ashford has struggled, with only 1,172 passing yards, two touchdowns, and four interceptions. Ashford missed Wake Forest's last game against Oregon State but should be good to go for this matchup.
This is a huge game in the race to get to the ACC Championship Game. SMU is one of three teams without a loss in the ACC this season. If they can get a win here, they will continue to control their own destiny in the race to get to the conference title game. But a loss for SMU would make their path to Charlotte much more difficult.
Score Projection: SMU 31 – Wake Forest 24
Win Probability: SMU 60%, Wake Forest 40%
SMU should be able to win by more than a field goal against Wake Forest on Saturday afternoon. There is no such thing as an easy road game in conference play. But the Mustangs are more consistent moving the ball through the air and that should get them out of any trouble that they find themselves in. I'll lay the points with SMU as they should stay unbeaten in ACC play for at least another week.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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