Wyoming vs San Diego State Pick & Prediction - 11/1/2025
Updated July 9, 2026
The Wyoming Cowboys (4‑4, 2‑2 Mountain West) will head west to face the San Diego State Aztecs (6‑1, 3‑0 MW) at Snapdragon Stadium in San Diego. The Aztecs are firmly in control of their destiny in the Mountain West Conference and they will try to avoid their first conference loss of the season against a struggling Cowboys team. Here, I break down this MWC matchup and you can find my Wyoming vs San Diego State prediction below.
Aztecs Jayden Denegal has managed games well. He has thrown just three interceptions this season and avoiding turnovers is all a quarterback needs to do in this system given how much SDSU relies on running the ball and playing defense. Wyoming's Kaden Anderson has shown promise, thanks in part to improved play‑calling under a new offensive coordinator. But his consistency is still lacking and he will face a much stiffer test against the Aztecs secondary.
The Aztecs should win tonight and keep their unbeaten conference record alive. But I think that San Diego State will fail to cover the spread in this contest. Wyoming just needs to score around 20 points to be in great shape to cover here against a San Diego State team that is always content to bleed clock and play the field position game.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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