The Green Bay Packers (3-1-1) will travel to Glendale to face the Arizona Cardinals (2-4) in a Week 7 NFL matchup on Sunday. Arizona has lost four straight games and is dealing with key injuries, including quarterback Kyler Murray and wide receiver Marvin Harrison Jr. Green Bay will try to take advantage of that to get their second win in a row. Before kickoff from Glendale, continue reading to get my Packers vs Cardinals prediction for Sunday.
Our Packers vs Cardinals Pick
- Pick: Green Bay Packers -6.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Green Bay Packers vs Arizona Cardinals
- Date & Time: Sunday, October 19, 2025, 4:25 PM EDT
- Venue: State Farm Stadium, Glendale, AZ
- Broadcast: FOX
Packers vs Cardinals Odds
Bet Type | Line |
|---|
Spread | Packers -6.5 |
Moneyline | Packers -320 / Cardinals +260 |
Total | 44.5 |
Key Storylines
- Packers' Defensive Strength: Green Bay's defense has been impressive, allowing 18 or fewer points in four of five games this season. They rank 10th in scoring defense and would be much better than that if not for their 40-40 tie with the Dallas Cowboys earlier in the year.
- Cardinals' Injury Concerns: Arizona is dealing with significant injuries, including quarterback Kyler Murray and wide receiver Marvin Harrison Jr. Both players are questionable for the game, which could severely impact the Cardinals' offensive capabilities. Running back Emari Demercado, whose goal-line fumble led to a collapse against the Tennessee Titans, is also questionable.
- Packers' Road Performance: Despite being favored, Green Bay has yet to win on the road this season, going 0-2 against the spread in away games. But Green Bay will like its chances to win this week, especially with Murray banged up for Arizona.
Quarterback Play
- Jordan Love (Packers): Love has shown promise this season, throwing for 1,259 yards, nine touchdowns, and two interceptions. He isn't the most prolific passer in the league, but he is avoiding mistakes and keeping his offense on schedule.
- Kyler Murray (Cardinals): Murray's status is uncertain due to a foot injury. If he is unable to play, Arizona will likely start backup quarterback Jacoby Brissett. Brissett wasn't terrible against the Colts last week and could help the Cardinals compete in this contest.
Betting Trends
- Packers' Trends: Green Bay is 2-3 against the spread this season and 0-2 against the spread on the road. The under has hit in three of their five games this season.
- Cardinals' Trends: Arizona is 3-3 against the spread this season but they have lost four straight games straight up. They are 3-3 on over/unders for the year.
Packers vs Cardinals Model Projection
- Score Projection: Packers 27 – Cardinals 17
- Win Probability: Packers 61.4%, Cardinals 38.2%
Final Thoughts
The contrarian in me loves the idea of taking the Cardinals to cover the number in this contest. But I think that the Cardinals will struggle to keep up with the Packers whether or not Murray is able to line up under center for Arizona. I'll take the Packers to win and cover the spread here, extending their unbeaten streak to three games in a row.
Jay Sanin
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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