LSU vs Vanderbilt Pick & Prediction - 10/18/2025
Updated July 9, 2026
LSU and Vanderbilt will play in the SEC on Saturday afternoon. This is one of the biggest games of the weekend in college football, with both teams ranked in the top 20 in the country going into this game. Before it starts, continue reading to get my LSU vs Vanderbilt prediction for a game that will have a huge impact on the SEC title chase.
Spread | Moneyline | Total |
|---|---|---|
Vanderbilt −2.5 | LSU +115 / Vanderbilt −135 | Over/Under 48.5 |
LSU signal-caller Garrett Nussmeier has thrown for 1,413 yards through six games, with nine touchdowns and five interceptions. He does have a road win at Clemson under his belt this season and will try to pass another important road test here.
Vanderbilt quarterback Diego Pavia has been one of the most exciting players in college football. He has thrown for 1,409 passing yards, 14 touchdowns, and four interceptions. He also leads the Commodores in rushing with 352 rushing yards and two rushing touchdowns. Pavia can make plays with both his arm and legs, which will make things tough on LSU’s defense.
Score Projection: Vanderbilt 31 – LSU 27
Win Probability: Vanderbilt 62%, LSU 38%
Any Saturday where we get to watch Diego Pavia play football is a good Saturday. I think we will see the best of Pavia this week against an LSU team that is just 1-1 on the road for the season. My recommendation is to lay the points with the Commodores, who should avoid a second straight loss and keep themselves within striking distance in the race for the SEC title game.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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